[Certus/ certain; Oss/ bone]

Naturally-derived materials

CertOss uses a proprietary and precisely combined tissue scaffold made of naturally-derived materials, to achieve an optimum microenvironment, rich in signals capable of driving inductive bone performance. 2, 3, 4, 5, 6, 7

This off-the-shelf graft has higher than 95% porosity 8, 9, 10, with a stiffness optimized for bone cell differentiation 11, 12, 13, 14 and an optimal biomaterial surface area of resorbable crystalline Hydroxyapatite 15

In two separate studies, CertOss has shown the ability to actively drive a de novo bone mineralisation response at ectopic sites17, 18. The ability of grafts to form bone at ectopic sites has become a yardstick measure for the best grafts, including growth factor products containing Bone Morphogenetic Protein (BMP) like InfuseTM (Medtronic) and various Demineralised Bone Matrix products containing trace amounts of BMP. The ability of a cell-free, growth factor free graft like CertOss to elicit the same response as these products provides an exciting glimpse into the potential for this highly engineered tissue scaffold.


*For investigational use only, not approved for sale


Biomaterial Science. Applied.


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  17. Cunniffe GM et al Acta Biomater. 2015 September; (23): 82-90