CertOss*

[Certus/ certain; Oss/ bone]

Naturally-derived materials

CertOss uses a proprietary and precisely combined tissue scaffold made of naturally-derived materials, to achieve an optimum microenvironment, rich in signals capable of driving inductive bone performance. 2, 3, 4, 5, 6, 7

This off-the-shelf graft has higher than 95% porosity 8, 9, 10, with a stiffness optimized for bone cell differentiation 11, 12, 13, 14 and an optimal biomaterial surface area of resorbable crystalline Hydroxyapatite 15

In two separate studies, CertOss has shown the ability to actively drive a de novo bone mineralisation response at ectopic sites17, 18. The ability of grafts to form bone at ectopic sites has become a yardstick measure for the best grafts, including growth factor products containing Bone Morphogenetic Protein (BMP) like InfuseTM (Medtronic) and various Demineralised Bone Matrix products containing trace amounts of BMP. The ability of a cell-free, growth factor free graft like CertOss to elicit the same response as these products provides an exciting glimpse into the potential for this highly engineered tissue scaffold.

 

*For investigational use only, not approved for sale

CertOss

Biomaterial Science. Applied.

References

  1. O’Brien FJ et al. Biomaterials. 2005; 26(4):433-41
  2. Farrell E et al. Tissue Eng. 2006 Mar; 12(3):459-68
  3. O’Brien FJ et al. Technol Health Care. 2007; 15(1):3-17.
  4. Farrell E et al. Technol Health Care. 2007;15(1):19-31.
  5. Byrne EM et al. J Mater Sci Mater Med. 2008 Nov; 19(11):3455-63.
  6. Haugh MG et al. J Biomed Mater Res A. 2009 May; 89(2):363-9.
  7. Murphy CM et al. Cell Adh Migr. 2010 Jul 9; 4(3).
  8. Murphy CM et al. Biomaterials. 2010 31: 461–466.
  9. Murphy CM et al. J Biomed Mater Res A. 2016 Jan; 104(1):291-304.
  10. Tierney CM et al. J Biomed Mater Res A. 2009 Sep 2 91A(1):92-101
  11. Keogh MB et al. Acta Biomater. 2010 6(11):4305-13.
  12. Haugh MG et al. Tissue Eng Part A. 2011 May; 17(9-10):1201-8.
  13. Murphy CM et al. J Mech Behav Biomed Mater. 2012 Jul; 11:53-62.
  14. Lyons F et al. Clin Orthop Relat Res. 2014 Apr; 472(4):1318-28
  15. Gleeson JP et al. Eur Cell Mater 2010; 20: 218-230.
  16. Murphy CM et al. Acta Biomater. 2014 May; 10(5):2250-8.
  17. Cunniffe GM et al Acta Biomater. 2015 September; (23): 82-90
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