Advancing the process of tissue repair
Stem Cells occur naturally in the body and are the body’s raw materials. They can exist in an undifferentiated state until called upon because of injury or illness. Cells may be self-sustaining units of life, but they don’t live in isolation. Their survival depends on receiving and processing information from the outside environment. Importantly, cells also can communicate with one another — and change in response — by way of a variety of chemical and mechanical signals.
Cells sense their environment 1, and from that can modify their cell type to affect a tissue-specific repair. Cell signalling allows for specialization of groups of cells. Multiple cell types can then join together to form tissues, such as muscle, bone or blood.
Because of this ability to sense their environment, we are developing products like CertOss which provide powerful signals to endogenous cells, driving their differentiation into a particular type of cell and affect the coordination of tissue repair2. We call these Instructive Tissue Scaffolds™.
As a spin-out from a leading school of Pharmacy – we are passionate about the controlled release of both large and small molecules. Bone is a slow healing tissue, and the controlled and extended-release of molecules should be optimised to better match the biological need. We call this approach Programmed Drug Release.
We bring the two distinct competencies of Instructive Tissue Scaffolds™ and Programmed Drug Release into our product design and development process so that we can bring the next generation of orthobiologics to surgeons and their patients.
Periprosthetic joint infection (PJI) is one of the most devastating and costly complications following total joint arthroplasty (TJA). Given the increase of TJA being performed annually, the number of...
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- Universidad de Barcelona. “Cells sense their environment to explore it.” ScienceDaily. ScienceDaily, 13 December 2017.
- Data on file from study LBI2022-1IM