CertOss is being developed through a disciplined R&D process that evaluates a variety of geometries to deliver a novel, 100% synthetic bone graft.
It brings together key discoveries by leading scientists in the field from the last 30 years. Our proprietary graft builds on the discovery by Ripamonti, that new bone was formed preferentially in the concave surfaces of a ceramic bone graft when implanted into muscle1.
Further research by Fukuda supported this finding that new bone was able to form in the centre of titanium tubes implanted into muscle2.
Finally, we incorporate the latest research on the importance of surface topography, as described by Davison, that submicron surface feature differences between the same ceramic material result in new bone mineralisation in a muscle pouch, whereas micron-scaled surface features did not3.
We combine these key principles to form an Instructive Tissue Scaffold™ called CertOss™.
*For investigational use only, not approved for sale
References
- Ripamonti U., J. Cell. Mol. Med. Vol 8, No 2, 2004 pp. 169-180
- A. Fukuda et al., Acta Biomater. 7 (5) (2011) 2327
- Davison Eur Cell Mater. 2015 Jun 20;29:314-29
