{"id":2398,"date":"2022-05-24T00:24:41","date_gmt":"2022-05-24T00:24:41","guid":{"rendered":"https:\/\/locatebio.com\/bmp2-white-paper\/"},"modified":"2022-05-24T00:24:41","modified_gmt":"2022-05-24T00:24:41","slug":"bmp2-white-paper","status":"publish","type":"post","link":"https:\/\/locatebio.com\/us\/bmp2-white-paper\/","title":{"rendered":"Programmed Drug Release of rhBMP-2 for Bone Healing"},"content":{"rendered":"<h2><b>PROGRAMMED DRUG RELEASE OF rhBMP-2 FOR BONE HEALING<\/b><\/h2>\n<div><\/div>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400;\">Non-union of bone fractures can cause pain and disabilities. Amongst certain fracture types, in specific age groups, the incidence of non-union is over 8% in the United States and over 3.6% of all fractures in the UK. Fracture non-unions have lifelong consequences and a debilitating impact in patients\u2019 life. Bone-grafts, allografts and xenograft are currently used to treat bone fractures; however, they have limitations. To overcome these limitations, we herein present a synthetic bone graft substitute composed of P<sub>DL<\/sub>LGA and rhBMP-2. We have demonstrated the suitability of this bone graft substitute both in <em>in-vitro<\/em> and <em>in-vivo<\/em> models. In the <em>in-vitro<\/em> model, rhBMP-2 release was sustained for 28 days. In the <em>in-vivo\u00a0<\/em>animal studies, the bone graft substitute showed both osteoinductive potential with ectopic bone formation in a rat muscle pouch, as well as osteogenic potential confirmed by the effective bone and mineral formation in a rabbit posterolateral vertebral fusion study.<\/p>\n<p>A PDF copy of the full White Paper can be downloaded below.<\/p>\n<p><a class=\"cta button primary button\" href=\"https:\/\/locatebio.com\/wp-content\/uploads\/2022\/05\/BMP2-White-Paper.pdf\">Download PDF paper<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PROGRAMMED DRUG RELEASE OF rhBMP-2 FOR BONE HEALING &nbsp; Non-union<\/p>\n","protected":false},"author":1,"featured_media":2399,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[40],"tags":[],"class_list":["post-2398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resources-us"],"acf":[],"_links":{"self":[{"href":"https:\/\/locatebio.com\/us\/wp-json\/wp\/v2\/posts\/2398","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/locatebio.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/locatebio.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/locatebio.com\/us\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/locatebio.com\/us\/wp-json\/wp\/v2\/comments?post=2398"}],"version-history":[{"count":0,"href":"https:\/\/locatebio.com\/us\/wp-json\/wp\/v2\/posts\/2398\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/locatebio.com\/us\/wp-json\/wp\/v2\/media\/2399"}],"wp:attachment":[{"href":"https:\/\/locatebio.com\/us\/wp-json\/wp\/v2\/media?parent=2398"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/locatebio.com\/us\/wp-json\/wp\/v2\/categories?post=2398"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/locatebio.com\/us\/wp-json\/wp\/v2\/tags?post=2398"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}