CognitOss Putty*

Despite advances in surgical techniques and fixation, the treatment of open tibial shaft fractures continues
to be associated with high rates of delayed union and nonunion.1, 2, 3

Delayed healing of tibial fractures is reported to be more likely in the presence of infection.4, 5 which increases the risk to the patient of amputation.

Still in stealth mode – CognitOss Putty is being developed to bring together all the key advances we have made on Instructive Tissue Scaffolds from CertOss Conduit, and Programmed Drug Release of both rhBMP-2 from LDGraft and antibiotics from CognitOss Foam


*For investigational use only, not approved for sale

  1. Bonatus T, Olson SA, Lee S, Chapman MW. Nonreamed locking intramedullary nailing for open fractures of the tibia. Clin Orthop. 1997;339:58-64.
  2. Riemer BL, DiChristina DG, Cooper A, Sagiv S, Butterfield SL, Burke CJ 3rd, Lucke JF, Schlosser JD. Nonreamed nailing of tibial diaphyseal fractures in blunt polytrauma patients. J Orthop Trauma. 1995;9:66-75.
  3. Edwards CC, Simmons SC, Browner BD, Weigel MC. Severe open tibial fractures. Results treating 202 injuries with external fixation. Clin Orthop.
  4. Caudle RJ, Stern PJ. Severe open fractures of the tibia. J Bone Joint Surg Am. 1987;69:801-7.
  5. Sanders R, Jersinovich I, Anglen J, DiPasquale T, Herscovici D Jr. The treatment of open tibial shaft fractures using an interlocked intramedullary nail without reaming. J Orthop Trauma. 1994;8:504-10.