Chondro3*

Chondro3 is our pioneering solution to the difficulty of treating osteochondral lesions. These can occur in any joint but are most common in the knee and ankle. Such lesions are a tear or fracture in the cartilage covering one of the bones in a joint and involved damage to both the cartilage and a piece of the underlying bone.

Osteochondral lesions can occur from an acute traumatic injury to the knee or an underlying bone disorder. They impact the lives of hundreds of thousands of patients every year. There is a clear and enduring unmet need for a true regenerative solution that can be delivered in a single procedure, in an outpatient setting and at an affordable price.

Just as with LDGraft, our goals for Chondro3 are both ambitious and based on a product profile with no room for compromise.

To succeed, we believe the graft should:

  1. Promote the repair of the damaged cartilage and underlying bone at the same rate.
  2. Allow seamless integration of the graft into the local host tissues.
  3. Have significant porosity to allow for cells and nutrients to move into the graft and for waste to be removed.
  4. Consistently drive the regeneration of long-lasting hyaline cartilage (chondrogenesis) and bone repair (osteogenesis) by incorporating powerful signalling mechanisms without the need to adds cells or growth factors.
  5. Mimic evolution by having a tidemark transition layer that will offer protection to the cartilage layer from:
    1. Bone overgrowth and
    2. The destructive shear forces at the interface between the hard, bony tissue and the rubbery cartilage layer.

With multiple peer-reviewed, published pre-clinical data showing the consistent production of hyaline cartilage, we are very excited by the significant opportunity that Chondro3 brings.

 

*For investigational use only, not approved for sale

Chondro3 Overview

Regenerative potential. Unlocked.

Author/s Title Publication
Levingstone TJ, Stack JD, O’Brien FJ et al (2016) Repair of large osteochondritis dissecans lesions using a novel multilayered tissue engineered construct in an equine athlete. J Tissue Eng Regen Med. 2016 Epub ahead of print PMID: 27198896
Levingstone TJ, Gleeson JG, O’Brien FJ et al (2016) Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits. Acta Biomater. 2016 Mar 1;32:149-60
Levingstone TJ, Gleeson JG, O’Brien FJ et al (2016) Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints. Biomaterials 87: 69-81
Matsiko A, Levingstone TJ, Gleeson JG, O’Brien FJ (2015) Incorporation of TGF-Beta 3 within Collagen-Hyaluronic Acid Scaffolds Improves their Chondrogenic Potential. Adv Healthc Mater. 2015 Jun;4(8):1175-9
Levingstone TJ, Gleeson JG, O’Brien FJ et al (2014) A biomimetic multi-layered collagen-based scaffold for osteochondral repair. Acta Biomater. 2014 May;10(5):1996-2004
Matsiko A, Levingstone TJ, O’Brien FJ (2013) Advanced strategies for articular cartilage defect repair Materials 6: 637-668
Matsiko A, Levingstone TJ, Gleeson JG, O’Brien FJ (2012) Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering. J Mech Behav Biomed Mater. 2012 Jul11:41-52
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